If you are working full time in a good company, there will be no issues.

If you are working for Desi Consultancies you MAY get into issues.
Usually, if your case is straightforward (assuming no administrative processing,  PIMS verification etc), they'll issue your visa in 1-2 days.

If Administrative processing it may take from few days to few weeks.
If PIMS verification, usually takes about 5-10 days.

All depends on your luck, company etc.

Examples of questions they'll ask:
1. What company do you work for ? Where's it located ?
2. How much is your salary ?
3. What does your company do ?
4. Are you married ?
5. Can you show me your LCA and other H1b Documents ?
6. What's your job title and what do you do ?
7. Who's your client ? Your vendor ? (** if you are working through desi consultancies mostly)
8. Can i see your pay stubs ?
9. Do you have your tax documents with you ?

These are just few examples, they can ask you anything.


How do i know ?
I appeared for H1B visa interview at Kathmandu recently !

Good Luck.