Most probably, She won't get a visa if she says truth. Yaa, if there is alternative way( lie ). And, if the immigration finds that she lied to get a visa then she might be sent back home from the US custom (worse case). I know one lady lied to get visa at the interview then she was caught at the US immigration and sent her back. It was a same case as yours, even the guys was US citizen. She lied at the embassy that she was single.
there is always chance but think before apply. I prefer to wait for her own immigration petition.