Posted by: On The Rocks March 17, 2010
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No, We don't have to apply for visa again unless you are out of US for more than 5 months or you here in US but not able to maintain your F1 status for 5 months.
If you are out of US for more than five years or been here but not able to maintain your status for 5 months, your visa get expired automatically.... even though it looks like a valid visa in your passport, it actually will be expired and could not be used to re enter to US.
I have confirmed this with a US consular .
Thanks