Weather-wise (Among World's best weather): San Diego/Southern California cities

Opportunites: New York, San Francisco, Seattle, Dallas, Boston, San Diego, DC

Party & lots of things to do: New York

City Life: New York, LA

Students with limited Budget go to Minnesota (for in-state tuition), Texas (for easy job in gas stations) or whereever you can manage your costs.

People with degrees go whereever you get the job, or where you have the best opportunities in your field, for example IT go to SF or for biotech such as boston or san diego or new jersey.

It again comes down to how you want to live, if you  move to California the cost of living would be higher but you apparantly do not have to deal with cold weather that much. So its give or take one way or the other. So simply asking what best place in the US to relocate is not enough, there are so many parameters such as crime rates, opportunities, job in your field, family-life, how you want to live, weather, schools for your kids and list goes on.....