Sampada ji,

First of all, your relatives should apply for the Social Security Card which won't take too long (usually withing a month!). Once they have SSCard in hand, their children be enrolled in a nearby school and the parents should search for job.  Local classified is a good source of information. A brief CV and English proficiency is  important tools in job hunting. They should be prepared  to take any job that come first and stay with that until they find better one.

If they live in the area where public transportation is not reliable, I strongly suggest them to learn driving as soon as possible because driving skill makes a big difference in day to day life as well as in job search.  You are right; they will have to struggle a lot in the beginning; particular in the first year. Like loratadine ji pointed out above, it takes time to get settled and they will be alright !