trek, you have two options: route 101 from SF to LA will be an adventure. its a route by the ocean and santa barbara. but the traffic will be very heavy especially during the weekends. be prepared to get stuck for a couple of hours especially when you get to the barbara area. I-5 would've been a better route if it weren't for those never ending farms and livestock smell ;). pick and choose! places to be in SF: bay bridge, golden gate, alcatraz island, downtown driving (have you ever seen such steep roads?), lombard street, pier 39 etc. you can get on a cruise to tour the bay as well. in LA: hollywood blvd, beverly hills area, rodeo drive, griffith observatory (if you want to take a photo with LA downtown in the background), malibu beach, laguna beach, disneyland, universal theme park.