Oh, yes, If your wife hasn't applied for CGFNS certificate and Florida Board of RN doesn't accept application without SSN, then Madhav's suggestion is the best option for you. California Board of Nursing accepts the application for licensure by examination without SSN. Believe me some Nepali nurses have passed NCLEX-RN for CABN from Hong Kong. However, the board doesn't issue permanent license without a SSN. Once your wife passes the NCLEX-RN test, any hospital in California can sponsor for a Green Card. CA board of Nursing supplies a letter addressed to INS which states that the applicant meets all the licensing requirement except SSN. INS approves EAD and I-140. Once your wife gets EAD, she applies for SSN, gets the CA permanent license and completes the visascreen certificate process. There you go... your green card is approved in 9-12 months (The assumption is your wife has completes the requirement of VisaScreen certificate in time including all the English proficiency requirement). While all these processes take time, you will have finished your degree and ready to go on 1 year OPT in California. California is the best place for foreign nurses to work.