Write me an email with current status. Has your wife already passed CGFNS certificate? Or, Has she already passed NCLEX-RN exam? First make sure your wife has at least one of these two things accomplished while on F2 status. If one of these applies to your wife, SSN is not a problem. Your wife can find a sponsoring employer and can apply directly for Green Card instead of changing status as non-immigrant. However, wife must have VisaScreen Certificate in hand before her green card is approved. I hope you are familiar with VisaScreen certificate process by this time. I will tell you the process in detail when you write. [Click on my name and send email via Sajha email system.]