Newuserji, I think u already have valuable suggestions. As a PhD student in Basic medical sciences, I may want to add some more details into it. If you visit websites of all most all research Univ. you will find two kind of programs offered by college of medicine- MD and PhD programs (in interdisciplinary gradate program in basic/biomedical sciences, now the new challenges in biomedical research has lead to chance the old dogma of awarding departmental PhD program in specific area like PhD in Pharmacology/pathology/microbiology/biochemistry/molecular biology.. now a biomedical researcher deemed to have knowledge from all of the areas of biomedical sciences ranging from Cellular and molecular biology to neuroscience to almost everything!!! So they are focusing on interdepartmental graduate program) and i think this would be the best option for your brother. They accept senior undergrad students directly into the PhD program (but are supposed to complete undergrad at the time of their matriculation into PhD program). They offer very generous stipend (around 20K/year) and full tuition and health and life insurance (at least in my Univ). Since your brother is in Nepal and is not perusing 4 years BS, I have serious doubt that they would accept him into the PhD program. So he has got two options as someone (Himal?) has already suggested- complete 4 years BS from Nepal or India (which I did) and join Masters program in Biology/biomedical science related program in here (which I did in my case) and then join PhD program or transfer here in junior year and get good grade (need at least GPA of 3.0 and good GRE score) and then directly apply into PhD program. My personal experience is that as F-1 student, it?s relatively difficult to inter into college of medicine (during my first visit to my graduate program director, she blatantly said to me that they generally do not accept non-USA student into the college of medicine until and unless u have excellent recommendation and grades and standardized test scores I guess I had all of them and I think my MS from here helped me to earn good recommendation in particular and I was accepted without an interview by the admission committee!!). The second option looks better to me. I think this is the program to go for if anyone is willing to peruse graduate program in biomedical/biotechnology related fields( I don?t think that MS is better option if u really want to see your future in biomedical research!!). You may want to go through the following web link from my Univ-http://southmed.usouthal.edu/com/bmsphd/index.htm Nut