How are you deducting 40K when you are earning only 75K? Do you have your own business or are you working as independent contractor? Seriously 40K deduction in just mileage and charitable contribution is hell lot of money when you are just making 75K and IRS will probably audit you.
Since you are making 150K total as household income you are under 25% tax bracket which is good for you otherwise if you have gone up even 3K you would be under 28% tax bracket.
Anyway, you don't need to worry about these because turbo tax will give you a best advice. In my opinion except your HUGE deduction on mileage and charitable contribution, you will good with married filing jointly. Also I am confused how your wife can deduct when you already deducted 40K.
By the way as a financial advice, you are paying 22K interest paid that's extremely high