Manager in Bank, probably he has advanced degree and already settled in Nepal and i guess he is close to 30s,
He need to start from 0 in USA, so probably very tough for husband to settle in USA with good profession.
Wife BN degree may not be equivalent to 4 years degree only US recognize Bsc Nursing (plus two and 4 years college) so she may not qualify to apply for Master Program. Start from under gradaute/ F1 status dependent husband it will be very challenging for both of them (financial and other aspects).

I believe canada is good straight forward PR , nursing easy to get job, and husband can run small business or study.

I do not know which option is fit for them it depends....

Good Luck to western world.

Thanks @gaulejetho for your input. I had the same advice initially and they even try to get some more details but looks like they won't get enough points to get PR to Canada. He was saying that they will most probably get around ~370/380 but the minimum points required is 420+. I haven't done any research on Canada PR if things got changed these days but I had a thought that they could easily get PR as he has Masters degree and his wife has 3 yrs BN. They even checked with consultancy and consultancy also told them that it's difficult for Canada so try for Australia which I did not advice to do so. They are now not thinking about Aus
Only option is US or Canada. His wife was saying that some people even take RN exam from India and can come in H1B. I was so surprised if that really happens. May be some indian dalal trying to grab some money. I don't know.

Input from other experienced folks are always welcome :)

For Canada, nowadays the points are running above 440. Recently it has been very high. Second, with 3 years BSN, the university won't accept at Masters level. She will have to enroll in undergraduate program again (although some credit might be transferred depending on the university, so take it to be 3 years to complete bachelors again). Nursing is not under Stem so she only gets 1 year opt after graduating and H1B is also very difficult as most hospitals don't want to sponser (and also have to deal with uncertainty of getting the lottery). I don't believe the Indian story as RN are taken very seriously here, you have to take RN for sure ( I know people who did but they had come here with 4 year BSN and with green card so no visa issue). I think going to Canada even on student visa seems like a much better deal than coming to US.

@roomrent969: Living abroad is a brainwashed concept. There is nothing better like living in your own country. Yes, you should definitely travel to other countries but living in someone else's country means you have to be ready for depression, high amount of stress which can cause PTSD and shedding tears of blood. In the end, most likely you will end up returning back to Nepal so what's the point?