An HR lady explicitly told me that all they are looking for a "modicum of humility", and the best approach is to be honest, as in every other situation. I think the idea is to have some to work with who doesn't act like a know it all, and constantly flaunts his expertise making other people gag every time they see this new aHole. As an example, If you are applying to be a developer you can tell them that you still have not mastered skripting, i.e. javaskript, as much as you would like to, and that is a weakness you seek to improve on. You could then go on a tangent, tell them that you are looking to improve on it with some online classes.