I guess DePaul has a better bussiness program than Loyala. So, I would assume getting into DePaul's MBA program will be more difficult compared to Loyala. Are you thinking about full-time or part-time MBA? DePaul has a highly ranked part-time MBA program. If you can get accepted at both schools, I would pick DePaul over Loyala. You can also check out MBA program at North Park University (as a back up) if you are thinking about doing MBA in Chicago.