If you are talking about the multivitamin capsules then there is no calories in them. If you are talking about taking in multivitamin via different food sources then yes there is calorie aspect associated with them. However, taking multivitamin will not lead to weight loss because vitamins are merely enzymes which help carry out different reactions within the body rather than being energy source. Any excess amount of vitamins in the body is excreted out as the body does not store vitamin. So, taking in multivitamin might help you psychologically but not much biochemically.