Relocate to somewhere where jobs are relatively aplenty and climate is relatively mild. Avoid climatic extremes in the likes of Death Valley, CA or inner northern continental US and Alaska.

If you have young kids then you wanna move to somewhere that have public schools better rated than national average like Washington DC Metro.

If you are reaching retirement age, move to Alabama or Florida where taxes are more retirement friendly.

If you are looking for strong jobs market consider DC Metro.

If you are a party animal, consider Queens, New York where somebody will always figure out an occasion to celebrate.

For more affordable and stable real estate consider the Lone Star state of Texas or Nebraska, the good life state.

If you are worried about global warming and the rising sea-level consider the mile high city of Denver, CO.

No matter where you relocate to it's all about jobs jobs and jobs unless you have a million dollar sitting in your retirement account.

Good luck in your quest.