Sweetner and food additivies can be accepted to certain extent. However, FDA has recommended permitted level. Not only this but also coloring agent have negative health hazard. Furthermore, antioxidant like Vitamin C (Putative negative calorie diet) is well known since long, for scavanging free radicals (Reactive oxygen species). Diet , in major extent, has a profound effect in maintaining health. In contrast, from genetic point of view, a different gene called Leptin has been suspected. In accord with Tacoma, burning fat through exercise is the natural way to be healthy.