Thank you very much for your reply Highvoltage. I did not know that they would gain approx. 4 kgs in around a month. I was aware that they would gain some weight due to decrease in lipolysis but did not know how much. One of the key enzymes of glycolysis is Glucokinase whose activity is dependent upon insulin. Increasing tissue insensitivity might have negative effects on Glucokinase so that glycolysis pathway will be hindered.

we divided non-selective beta blockers as:
1. Non-selective beta blockers : like timolol or propanolol
2. Non-selective Beta antagonist +  Beta agonist = This group also have intrinsic sympathomimetic activity (ISA). Examples: carteolol, penbutolol, pindolol
3. Non-selective Beta antagonist + selective alpha1 antagonist = Carvedilol, Labetalol

And
1. Selective beta1 antagonist or cardioselective= esmolol, atenolol, or metoprolol