Posted by: highvoltage November 19, 2007
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very interesting topic in fact which has not fully been discovered but beta blocker does not directly affect beta cells of pancreas, in fact more on insulin sensitivity.
first of all it is wrong to say beta blocker can cause diabetes becoz it seldom does.but like coffee333 said in some patienst it may increase risk of diabetes, even can cause, but only on those patients who are on the verge of diabetes but the disease itself has not yet been exposed.
there r two types of beta blockers: a) cardioselective beta-1 receptor-blocker which works mainly in heart and b)non-selective beta-2 receptor-blocker which also works on other beta receptors for e.g. on bronchial receptors and periphere blood vessels.
this non-selective could also have effect on pancreas which has not yet been found.but how could these blockers have caused diabetes??these blockers have negative effect on lipid metabolism and insulin sensitivity due to which the body weight may increase upto 4 kilogramms in the first 5-6 weeks.may be in this process, glycolysis gets somewhat inhibited or negatively effected.the most important thing is beta blocker lowers the concentration of HDL which means the concentration of triglycerides are high which leads to worsening of glucosetolerance and this may have caused hypoglycemic symptomps.(like sweating ,positive chronotropy, feeling of hunger etc.).
astu:
first of all it is wrong to say beta blocker can cause diabetes becoz it seldom does.but like coffee333 said in some patienst it may increase risk of diabetes, even can cause, but only on those patients who are on the verge of diabetes but the disease itself has not yet been exposed.
there r two types of beta blockers: a) cardioselective beta-1 receptor-blocker which works mainly in heart and b)non-selective beta-2 receptor-blocker which also works on other beta receptors for e.g. on bronchial receptors and periphere blood vessels.
this non-selective could also have effect on pancreas which has not yet been found.but how could these blockers have caused diabetes??these blockers have negative effect on lipid metabolism and insulin sensitivity due to which the body weight may increase upto 4 kilogramms in the first 5-6 weeks.may be in this process, glycolysis gets somewhat inhibited or negatively effected.the most important thing is beta blocker lowers the concentration of HDL which means the concentration of triglycerides are high which leads to worsening of glucosetolerance and this may have caused hypoglycemic symptomps.(like sweating ,positive chronotropy, feeling of hunger etc.).
astu: