Here is the latest information: 50,000 nursing quota was added in 2005 when the regular EB-3 got retrogressed. Before that Nurses would file under the same EB-3 category but didn't have to go through the Labor Certification Process. That 50,000 quota was one time allottment which is going to expire at the end of this month or sooner. [Definately you can't file adjustment of status on or after November 1, 2006. However, whether you can continue to file until the end of October remains uncertain as there is no precise information on how many quotas are left. If the quota is left, you can continue to file until the end of this month]. Demand for nurses still remains at the alarming rate. There is good possibility that Congress will find some other way to give more immigration visas for nurses. However, until this happens, the application for I-485 is not accepted as the immigration visa will not be available. However, it doesn't stop you from filing I-140. As long as you have other non-immigration visa status to remain in the US and you have met the requirement for green card filing, go ahead with your regular application for I-140 (Pettition for Alien Worker). Acceptance of I-140 will set your priority date for future I-485 filing. However, you must have other visa status to legally remain in the US until the priority dates are current. At this moment, the priority date for Nurses is October 1, 2005 for nurses. Those who have already filed for I-485 in the past few months and haven't received the decision yet, will have to wait until their priority date is current. However, you can renew the work permit annually and will not have problem to stay and work in the US. You can also apply for Advance Parole if you need to travel out of the country.